Venlafaxine Besylate Er
Venlafaxine Besylate ER 112.5MG
What is Venlafaxine Besylate Er?
Venlafaxine Besylate ER is an extended-release formulation of venlafaxine besylate, a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily in the treatment of major depressive disorder, anxiety, and panic disorders. This medication works by regulating the levels of serotonin and norepinephrine in the brain, thereby improving mood and alleviating symptoms of depression and anxiety. The extended-release form allows for once-daily dosing and helps maintain consistent drug levels in the body.Side Effects
- Unusual behavior, thoughts of hurting yourself or others, trouble sleeping, nervousness, unusual dreams
- Feeling more excited or energetic than usual
- Seizures
Warnings
- This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased cholesterol levelsIncreased blood pressureIncreased risk of bleeding problemsLung problems, including interstitial lung disease and eosinophilic pneumoniaSexual problems
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, glaucoma, heart disease, high blood pressure, or thyroid problems. Tell your doctor if you have a history of mania, seizures, heart attack, or stroke.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. This will help decrease the risk of unwanted effects.
Prescription savings · · · ·
What is Venlafaxine Besylate Er ?
Venlafaxine Besylate ER is an extended-release formulation of venlafaxine besylate, a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily in the treatment of major depressive disorder, anxiety, and panic disorders. This medication works by regulating the levels of serotonin and norepinephrine in the brain, thereby improving mood and alleviating symptoms of depression and anxiety. The extended-release form allows for once-daily dosing and helps maintain consistent drug levels in the body.- Unusual behavior, thoughts of hurting yourself or others, trouble sleeping, nervousness, unusual dreams
- Feeling more excited or energetic than usual
- Seizures
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Blistering, peeling, red skin rash
- Chest pain, cough, trouble breathing
- Confusion, tiredness, weakness, and muscle twitching
- Fast or pounding heartbeat
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Unusual bleeding or bruising
- Eye pain, vision changes, seeing halos around lights
- Headache, dizziness, trouble concentrating, memory problems, unsteadiness
- This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased cholesterol levelsIncreased blood pressureIncreased risk of bleeding problemsLung problems, including interstitial lung disease and eosinophilic pneumoniaSexual problems
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, glaucoma, heart disease, high blood pressure, or thyroid problems. Tell your doctor if you have a history of mania, seizures, heart attack, or stroke.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. This will help decrease the risk of unwanted effects.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Headache, trouble concentrating, memory problems, unsteadiness
- Seizures
- Trouble sleeping, nervousness, unusual dreams
- Unusual behavior, thoughts of hurting yourself or others
- Unusual bleeding or bruising
Venlafaxine Besylate Er Coupons & Prices
Venlafaxine Besylate ER 112.5MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Venlafaxine Besylate Er prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 112.5mg · Tablet Extended Release 24 Hour | 30 | $232.99 | $206.38 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
If you're searching for a venlafaxine besylate ER coupon, it helps to know exactly what you're comparing: this is venlafaxine besylate extended-release tablets, an FDA-approved product built on the same active medicine used in brand-name Effexor XR, which is formulated with a different salt (venlafaxine hydrochloride). Venlafaxine besylate ER is approved in a single 112.5 mg strength and is not meant for starting venlafaxine treatment or for adjusting your dose. Pricing for it can still vary from pharmacy to pharmacy, so it's worth comparing before you fill. Rx.com checks pricing across more than 60,000 U.S. pharmacies so you can see where your prescription costs less before you hand over your card.
What is venlafaxine besylate ER and how does it work?
Venlafaxine besylate extended-release tablets belong to the SNRI (serotonin-norepinephrine reuptake inhibitor) class of antidepressants. It's FDA-approved to treat Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) in adults. It's taken once daily with food, and the tablet must be swallowed whole, never split, crushed, or chewed, since that can affect how the medication is released.
This product is available in only one strength, 112.5 mg. It is not approved for starting venlafaxine treatment or for titrating a dose up or down, that's done with other venlafaxine products that come in a range of strengths. If your prescriber has you on a different dose, this specific product may not match your prescription, so confirm with your pharmacist before filling.
Some doctors also prescribe venlafaxine ER off-label for hot flashes and other vasomotor symptoms, or for chronic neuropathic pain and migraine prevention. These are not this product's FDA-approved uses, and whether they're appropriate is a decision to make with your prescriber.
Venlafaxine besylate ER cost and how to compare prices
Venlafaxine besylate ER is a single-source, FDA-approved product rather than a medication stocked from many competing manufacturers, but cash prices for it can still differ substantially from one pharmacy to the next and by location. Rather than assuming one number applies everywhere, enter your ZIP code above to see today's price at pharmacies near you and pick the one that works best for your budget.
If you have insurance, your copay may or may not beat the cash price you'd get by comparing pharmacies directly, so it's worth checking both before you fill.
Venlafaxine besylate ER vs. Effexor XR and other options
Venlafaxine besylate ER is its own FDA-approved product, not an interchangeable generic that a pharmacy would routinely substitute for every venlafaxine ER prescription. It uses the besylate salt of venlafaxine rather than the hydrochloride (HCl) salt found in brand-name Effexor XR and in generic venlafaxine HCl ER, and its approval was supported by data showing bioequivalence to venlafaxine HCl ER 150 mg. Because it's approved in only one strength, it isn't a substitute across every venlafaxine ER dose, if your prescription is written for a different strength or a different product, ask your pharmacist to confirm which one you were prescribed before assuming this is it.
If venlafaxine isn't the right fit, other antidepressants your provider might discuss include desvenlafaxine (venlafaxine's active metabolite), duloxetine (another SNRI), or SSRIs like sertraline and escitalopram. Switching between antidepressant classes should always be guided by your prescriber, not done on your own.
Safety information for venlafaxine besylate ER
Venlafaxine besylate ER carries a boxed warning for increased risk of suicidal thinking and behavior in children, adolescents, and young adults younger than 25 (ages 18-24), particularly during the early weeks of treatment or after a dose change. It should not be taken within 14 days of an MAOI due to the risk of serotonin syndrome, and it can also raise serotonin syndrome risk when combined with other serotonergic medications.
- Can cause sustained increases in blood pressure; your provider should monitor this
- May increase bleeding risk when combined with NSAIDs, aspirin, or blood thinners
- Has been associated with angle-closure glaucoma
- Stopping abruptly can cause a significant discontinuation syndrome; dosage should be tapered under medical guidance, not stopped suddenly
- Should not be used for bipolar disorder without a mood stabilizer, due to risk of triggering a manic episode
This is general information, not medical advice. Talk to your doctor or pharmacist about whether venlafaxine besylate ER is right for you and how to take it safely.
This Venlafaxine Besylate Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Venlafaxine Besylate Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Related Drugs
Browse more medications: starting with V · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.