Xigduo Xr Coupons & Prices

Xigduo XR is a brand-name extended-release combination tablet containing dapagliflozin and metformin, used to help manage type 2 diabetes. If you're searching for a Xigduo XR coupon, Rx.com can help you compare cash prices at pharmacies near you, whether you have commercial insurance, Medicare, or no coverage at all — enter your ZIP above to see today's price.

What is Xigduo XR and how does it work?

Xigduo XR combines two medications in one extended-release tablet: dapagliflozin, an SGLT2 inhibitor that helps the kidneys remove excess glucose through the urine, and metformin, a biguanide that lowers glucose production by the liver and improves the body's response to insulin. It's FDA-approved, along with diet and exercise, to improve blood sugar control in adults and pediatric patients 10 years and older with type 2 diabetes. In adults with type 2 diabetes, it's also approved to reduce the risk of certain chronic kidney disease outcomes and heart failure hospitalization in specific patient groups, as described in the full prescribing information. Xigduo XR is taken with food and swallowed whole; it shouldn't be crushed, split, or chewed.

Manufacturer savings vs. an Rx.com cash coupon

Xigduo XR's manufacturer offers a savings card program for eligible patients with commercial insurance; program terms and eligibility vary and are subject to change, so check the manufacturer's official site for current details. That card generally isn't available if you're uninsured or covered by Medicare or Medicaid. In those cases, an Rx.com cash coupon can be used at the pharmacy counter instead. As of 2026, a marketed generic of this exact extended-release dapagliflozin/metformin combination tablet isn't broadly available in the U.S., so comparing pharmacy cash prices for the brand is worth doing before you fill. Metformin on its own is available as a low-cost generic; ask your doctor whether taking dapagliflozin and metformin as two separate prescriptions could be a lower-cost option for you.

Other type 2 diabetes medications

Other SGLT2 inhibitors, such as empagliflozin (Jardiance), work similarly to the dapagliflozin component of Xigduo XR and may be worth discussing with your doctor as an alternative. Dapagliflozin is also available on its own under the brand name Farxiga for patients who don't need the metformin combination. Your doctor will help decide which single or combination therapy fits your kidney function, heart health, and treatment goals.

Safety information

Xigduo XR carries an FDA boxed warning for lactic acidosis, a rare but serious buildup of lactic acid linked to the metformin component; risk is higher with kidney impairment, certain other medications, heavy alcohol use, liver disease, dehydration, or advanced age, and it can be fatal. Seek medical attention right away for symptoms like unusual muscle pain, difficulty breathing, unusual tiredness, or a slow or irregular heartbeat. The dapagliflozin component carries its own warnings, including a risk of diabetic ketoacidosis, a rare but serious genital/perineal infection called necrotizing fasciitis (Fournier's gangrene), urinary tract infections that can become serious, and dehydration that can lower blood pressure. Xigduo XR isn't recommended for patients with significantly reduced kidney function. This is general information, not medical advice — follow your doctor's specific instructions.