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Captopril Tablet — prescription drug image

Captopril

Captopril 25MG

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What is Captopril?

Captopril is used to treat hypertension, heart failure and other conditions as prescribed by your doctor. Captopril is a generic drug. On average, Captopril is priced at about $63 for a supply of 60, 25 mg tablets. You can use our Rx.com savings offer to get a Captopril discount of up to 80% off of the retail price at participating pharmacies near you.

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What is Captopril ?

Captopril is used to treat hypertension, heart failure and other conditions as prescribed by your doctor. Captopril is a generic drug. On average, Captopril is priced at about $63 for a supply of 60, 25 mg tablets. You can use our Rx.com savings offer to get a Captopril discount of up to 80% off of the retail price at participating pharmacies near you.
  • Blistering, peeling, red skin rash
  • Severe stomach pain (with or without nausea or vomiting)
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips
  • Change in how much or how often you urinate, cloudy urine, swelling in your feet or lower legs
  • Fever, chills, sore throat, body aches
  • Lightheadedness, dizziness, fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, heart or blood vessel disease, heart valve problems, diabetes, or an autoimmune disorder (including lupus or scleroderma).
  • This medicine may cause the following problems:Angioedema (severe swelling), including head, neck, and intestinal swellingLow blood pressureLiver problemsKidney problems
  • This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
  • Do not stop using this medicine without asking your doctor, even if you feel well. Tell any doctor or dentist who treats you that you are using this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is captopril used for?
Captopril is an ACE inhibitor approved to treat high blood pressure (alone or with a thiazide diuretic) and heart failure (usually along with a diuretic and digitalis). It is also approved for clinically stable patients after a heart attack who have left ventricular dysfunction with an ejection fraction of 40% or less, where it improves survival, reduces heart-failure hospitalizations, and slows progression to overt heart failure. And it is approved for diabetic nephropathy in people with type 1 diabetes who have retinopathy and more than 500 mg of protein in the urine per day, to slow kidney disease and reduce the risk of dialysis, transplant, or death.
Why do you have to take captopril on an empty stomach?
Food reduces how much captopril your body absorbs, so taking it with a meal can make it less effective. The label directs you to take it about one hour before meals. Try to take each dose at the same times each day so it becomes a routine, and ask your pharmacist if you are not sure how to fit the doses around your meals.
What are the most common side effects of captopril?
The best-known one is a persistent dry, nonproductive cough, which is a side effect of ACE inhibitors as a class and goes away after the drug is stopped. Captopril can also cause dizziness or lightheadedness from low blood pressure, especially if you are dehydrated or also take a diuretic, and it can raise potassium levels. Less common but serious problems include angioedema (sudden swelling of the face, lips, tongue, or throat), a drop in white blood cells, changes in kidney function, protein in the urine, and rarely liver injury. Get emergency help for any swelling of the face or throat or trouble breathing, and call your doctor about severe dizziness, fever or sore throat, or yellowing of the skin or eyes.
Is captopril the same as lisinopril, and why is captopril taken multiple times a day?
They are not the same drug, but they are in the same family. Both are ACE inhibitors that work the same basic way. Captopril was the first orally active ACE inhibitor approved in the U.S., and it is dosed two to three times a day and must be taken about an hour before meals because food cuts its absorption. Lisinopril and other newer ACE inhibitors can be taken once a day, which is easier to stick with, so they have largely replaced captopril for routine long-term treatment. Only your prescriber can decide whether a switch is right for you.
Why is captopril not safe during pregnancy?
Captopril carries a boxed warning for fetal toxicity. Drugs that act directly on the renin-angiotensin system can injure or kill a developing baby. Exposure during the second and third trimesters can reduce the baby's kidney function and cause low amniotic fluid, which in turn can lead to underdeveloped lungs and skeletal deformities, and newborns have had skull underdevelopment, no urine output, low blood pressure, kidney failure, and death. If pregnancy is detected, captopril should be stopped as soon as possible, so tell your doctor right away if you are pregnant or planning to become pregnant.
How much does Captopril cost without insurance?
The price of Captopril without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Captopril?
Common side effects of Captopril may include: Blistering, peeling, red skin rash, Severe stomach pain (with or without nausea or vomiting), Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips, Change in how much or how often you urinate, cloudy urine, swelling in your feet or lower legs. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Captopril?
Generic versions may be available for Captopril. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Captopril on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Captopril?
The cheapest pharmacy for Captopril depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Captopril near you.

Captopril Coupons & Prices

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Looking for a captopril coupon? Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, left ventricular dysfunction after a heart attack, and diabetic kidney disease. The brand name Capoten is no longer marketed in the U.S., but generic captopril tablets are widely available and are already one of the lower-cost blood pressure medicines. Cash prices still vary a lot from one pharmacy to the next, even across the street, so it pays to compare. Enter your ZIP code above to see today's captopril price at pharmacies near you and get a free coupon you can show at the counter.

What is captopril and how does it work?

Captopril is an angiotensin-converting enzyme (ACE) inhibitor, a type of medicine that acts on the renin-angiotensin-aldosterone system. It was the first orally active ACE inhibitor approved in the United States. By blocking the enzyme that makes angiotensin II, a hormone that tightens blood vessels, captopril helps blood vessels relax so blood can flow more easily and the heart does not have to work as hard.

The FDA-approved uses on the captopril tablet label are: high blood pressure (alone or with a thiazide diuretic such as hydrochlorothiazide); heart failure, usually along with a diuretic and digitalis; left ventricular dysfunction after a heart attack in clinically stable patients with an ejection fraction of 40% or less, to improve survival, reduce heart-failure hospitalizations, and slow progression to overt heart failure; and diabetic nephropathy (protein in the urine above 500 mg per day) in people with type 1 diabetes and retinopathy, to slow kidney disease and reduce the risk of dialysis, transplant, or death. Captopril is not a controlled substance.

How much does captopril cost without insurance?

Captopril is an older generic, so it is generally inexpensive compared with newer blood pressure drugs. That said, "inexpensive" is not the same as "the same everywhere." Cash prices for the exact same tablet, strength, and quantity can differ widely between a big chain, a grocery pharmacy, and an independent, because each pharmacy sets its own cash price. If you are paying without insurance, or if your plan's deductible has not been met, a discount coupon is often the cheaper way to pay.

Rx.com compares captopril prices across more than 60,000 pharmacies nationwide and shows you what the drug actually costs at each one today. Enter your ZIP code above, choose your strength and quantity, and bring the free coupon to the pharmacy counter. There is no manufacturer savings card for captopril, since the brand (Capoten) is discontinued in the U.S. and only the generic is sold. A few tips that usually lower the price: ask about a 90-day supply instead of 30 days, compare a couple of pharmacies before you transfer, and confirm the price before the pharmacy runs your insurance, since the coupon price and the insurance copay cannot be combined.

Captopril vs. other ACE inhibitors and alternatives

Captopril has to be taken two or three times a day, about an hour before meals, because food reduces how much of it your body absorbs. That inconvenience is the main reason once-daily ACE inhibitors have largely replaced it for routine long-term treatment. Ask your prescriber whether one of these is a better fit for you:

  • Lisinopril - a once-daily ACE inhibitor and the most commonly prescribed one
  • Enalapril, ramipril, benazepril, and quinapril - other ACE inhibitors with less frequent dosing
  • Losartan - an ARB, a different class often used when an ACE inhibitor's dry cough is not tolerated
  • Hydrochlorothiazide - a thiazide diuretic that is often combined with an ACE inhibitor (captopril was once sold with it as the discontinued brand Capozide)

Captopril should not be taken together with an ARB such as losartan, because blocking the renin-angiotensin system two ways at once raises the risk of low blood pressure, high potassium, and kidney problems. Never switch or stop a blood pressure medicine on your own. This page is information, not medical advice, so talk with your prescriber about which option fits your health history.

Captopril safety, warnings, and side effects

Boxed warning - fetal toxicity. Medicines that act directly on the renin-angiotensin system can injure or kill a developing baby. If you become pregnant or think you may be pregnant, tell your doctor right away so captopril can be stopped as soon as possible. Exposure in the second and third trimesters can reduce the baby's kidney function and lead to low amniotic fluid, underdeveloped lungs, skull and skeletal problems, low blood pressure, kidney failure, and death.

Other important warnings on the label: angioedema, a sudden swelling of the face, lips, tongue, throat, or voice box, which can be life-threatening if it blocks the airway and needs emergency care immediately (it has been reported more often in Black patients, and intestinal swelling has also occurred); a drop in white blood cells (neutropenia or agranulocytosis), with the highest risk in people who have kidney impairment, especially those who also have a collagen vascular disease; symptomatic low blood pressure, particularly if you are dehydrated or on diuretics or dialysis; high potassium, which is more likely with kidney problems, diabetes, potassium supplements, potassium-sparing diuretics, or salt substitutes that contain potassium; worsening kidney function; a persistent dry, nonproductive cough that is common to this whole drug class and goes away after stopping; and, rarely, protein in the urine or liver injury. Captopril should not be used by anyone with a history of angioedema caused by an ACE inhibitor or hereditary angioedema, should not be combined with aliskiren in people with diabetes, and should not be started within 36 hours of taking a neprilysin inhibitor (sacubitril/valsartan). Report severe dizziness, swelling, trouble breathing, fever or sore throat, or yellowing of the skin or eyes to your doctor promptly. This is a summary, not a complete list, and it is not a substitute for your provider's or pharmacist's advice.

Sources & accuracy

This Captopril information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Captopril on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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