Clobazam
cloBAZam 10MG
What is Clobazam?
Clobazam is a benzodiazepine class medication typically prescribed for the management of anxiety and to control seizures, particularly in conditions like Lennox-Gastaut syndrome. It works by enhancing the activity of neurotransmitters in the brain to produce a calming effect, helping to reduce the frequency and intensity of seizures and ease anxiety symptoms. Clobazam is designed for short-term use due to the risk of dependency with long-term use.Side Effects
- Extreme tiredness or weakness, slow heartbeat, trouble breathing
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
Warnings
- Birth control pills may not work as well when used with this medicine. Use a second form of birth control to keep from getting pregnant and for 28 days after your last dose.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may return or occur more often if you stop using this medicine suddenly.
- This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Prescription savings · · · ·
What is Clobazam ?
Clobazam is a benzodiazepine class medication typically prescribed for the management of anxiety and to control seizures, particularly in conditions like Lennox-Gastaut syndrome. It works by enhancing the activity of neurotransmitters in the brain to produce a calming effect, helping to reduce the frequency and intensity of seizures and ease anxiety symptoms. Clobazam is designed for short-term use due to the risk of dependency with long-term use.- Extreme tiredness or weakness, slow heartbeat, trouble breathing
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Blue lips, fingernails, or skin
- Blurred vision, change or loss of consciousness, lightheadedness, dizziness, or fainting, problems with coordination or walking, unusual drowsiness or sleepiness
- Depression, anxiety, irritability, hallucinations, trouble sleeping, unusual behavior, thoughts of hurting yourself or others
- Confusion or unusual excitement, nervousness, irritability
- Birth control pills may not work as well when used with this medicine. Use a second form of birth control to keep from getting pregnant and for 28 days after your last dose.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. Your seizures may return or occur more often if you stop using this medicine suddenly.
- This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine during the later part of a pregnancy may cause problems in your newborn baby (including sedation or withdrawal symptoms). Tell your doctor right away if you think you have become pregnant.
- Tell your doctor if you are breastfeeding or planning to breastfeed. This medicine passes into your breast milk and may cause problems in your baby. Talk to your doctor about the best way to feed your baby.
- Tell your doctor if you have kidney disease, liver disease, lung disease or breathing problems, or a history of alcohol or drug abuse, depression, or a mood disorder.
- This medicine may cause the following problems:Increased risk of overdose, which can be life-threateningRespiratory depression (serious breathing problem that can be life-threatening), when used with narcotic pain medicinesSerious skin reactions
Clobazam Coupons & Prices
cloBAZam 10MG
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A clobazam coupon from Rx.com can lower what you pay at the pharmacy counter when you are paying cash instead of using insurance. Clobazam is the active ingredient in Onfi (tablets and oral suspension) and Sympazan (oral film). Generic clobazam is available as tablets and oral suspension; the oral film is currently brand-only. It is FDA-approved as an add-on treatment for seizures associated with Lennox-Gastaut syndrome in people 2 years of age and older. The cash price for clobazam swings a great deal from one pharmacy to the next, even between stores on the same street, so it is worth comparing before you fill. Rx.com compares prices at more than 60,000 pharmacies nationwide, so you can see where your prescription is cheapest today. Enter your ZIP code above to see today's price near you and print, text, or email your free coupon.
What is clobazam and how does it work?
Clobazam is a benzodiazepine (specifically a 1,5-benzodiazepine) used as an antiepileptic, or anti-seizure, medicine. It works in the brain as a positive allosteric modulator at GABA-A receptors, which means it strengthens the effect of GABA, the body's main calming chemical messenger. Boosting that calming signal makes the abnormal electrical bursts that cause seizures less likely to spread.
In the United States, the only FDA-approved use for clobazam and for its brand-name versions is the adjunctive (add-on) treatment of seizures associated with Lennox-Gastaut syndrome in patients 2 years of age and older. That approval covers Onfi tablets and oral suspension, the Sympazan oral film, and generic clobazam tablets and oral suspension. Neurologists sometimes prescribe clobazam for other seizure disorders, but those uses are outside the FDA-approved labeling and are a decision for your prescriber, not something to start or change on your own. Outside the US the drug is sold as Frisium and carries different approved uses there. This page is information only, not medical advice, so talk with your neurologist or pharmacist about what is right for you.
Clobazam cost without insurance, and how a coupon helps
Generic clobazam is widely stocked as tablets and as an oral suspension, and generics are typically the lower-cost option compared with the brand-name products. But that does not mean the price is the same everywhere. Cash prices for the very same strength and quantity of clobazam can differ dramatically between a big chain, a grocery-store pharmacy, and an independent down the road, because each pharmacy sets its own cash price. That is the single biggest reason it is worth comparing before you fill.
Rx.com compares cash prices at over 60,000 US pharmacies and shows you a free discount coupon you can use even if you have no insurance at all. A few things worth knowing:
- The coupon is for cash-pay prescriptions. It is not insurance, and it cannot be combined with your insurance benefit on the same fill.
- Sometimes the cash coupon price beats a plan copay and sometimes it does not. It is fine to ask the pharmacist to check both and ring up whichever is lower.
- Price depends on strength, quantity, dosage form, and location, so run your exact prescription rather than assuming. Generic clobazam comes as tablets and as an oral suspension; the oral film is available only as brand-name Sympazan, so a coupon price for the film is a brand price, not a generic one.
- There is no manufacturer savings card for generic clobazam. The brand oral film, Sympazan, is supported by its manufacturer's official website, where any savings program terms and eligibility rules are posted and can change at any time.
Enter your ZIP above to see today's clobazam price at pharmacies near you.
Clobazam vs. clonazepam and other seizure medicines
Clobazam is often confused with clonazepam. Both are benzodiazepines used in epilepsy, but they are different molecules with different chemistry: clobazam is a 1,5-benzodiazepine, while clonazepam and the other familiar benzodiazepines such as lorazepam and diazepam are 1,4-benzodiazepines. In practice, clobazam's US approval is narrowly for add-on treatment of Lennox-Gastaut syndrome seizures, and it tends to be chosen when a prescriber wants benzodiazepine seizure control as a daily add-on. They are not interchangeable, and switching between them is a prescriber's decision.
Clobazam is almost always used alongside a non-benzodiazepine anti-seizure medicine rather than by itself. Common companions in Lennox-Gastaut syndrome and other epilepsies include lamotrigine, valproic acid, topiramate, rufinamide, and levetiracetam. If cost is your concern, the answer is usually not to change medicines but to shop the price of the one you were prescribed. Compare your exact clobazam prescription across nearby pharmacies first, and bring any real affordability problem to your prescriber before you skip or stretch doses.
Safety, side effects, and important warnings
Clobazam is a Schedule IV (C-IV) controlled substance and carries an FDA boxed warning with three parts. First, taking it with opioids can cause profound sedation, slowed or stopped breathing, coma, and death, so the combination should be reserved for people with no other option, at the lowest dose and shortest duration, with close monitoring. Second, even at recommended doses, benzodiazepines carry a risk of abuse, misuse, and addiction that can lead to overdose or death. Third, physical dependence can develop after continued use of only several days to weeks, and stopping suddenly or cutting the dose too quickly can trigger acute withdrawal, including life-threatening reactions such as seizures and status epilepticus. Clobazam should be tapered gradually under a prescriber's direction, never stopped on your own.
Other important risks to know about: serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS, have been reported, so report any new rash to your prescriber right away. Sleepiness and sedation are very common and are worse with alcohol or other sedating medicines, so avoid alcohol. Antiseizure medicines as a class can raise the risk of suicidal thoughts or behavior. Breathing problems are a particular concern in people with compromised respiratory function. Use during pregnancy can cause sedation and withdrawal in a newborn. People with liver problems and CYP2C19 poor metabolizers need lower starting doses and slower dose increases. Clobazam can make hormonal birth control less effective, so an additional non-hormonal method is recommended. Older adults face a higher risk of sedation and falls. This is a summary, not a complete list, and not medical advice; read the medication guide and ask your pharmacist or prescriber about your own situation.
This Clobazam information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Clobazam on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.