Colchicine
Colchicine
What is Colchicine?
Colchicine is a prescription medication commonly used to treat and prevent gout attacks by reducing the inflammation caused by uric acid crystal buildup in the joints. It may also be prescribed for certain inflammatory conditions, including familial Mediterranean fever, and should be taken exactly as directed due to its narrow therapeutic range.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding, bruising, or weakness
- Bloody or black tarry stools, red or dark brown urine
Warnings
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia, bleeding problems, or muscle problems.
- This medicine may cause severe muscle problems.
Prescription savings · · · ·
What is Colchicine ?
Colchicine is a prescription medication commonly used to treat and prevent gout attacks by reducing the inflammation caused by uric acid crystal buildup in the joints. It may also be prescribed for certain inflammatory conditions, including familial Mediterranean fever, and should be taken exactly as directed due to its narrow therapeutic range.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding, bruising, or weakness
- Bloody or black tarry stools, red or dark brown urine
- Pale or gray lips, tongue, or palms
- Fever, chills, cough, sore throat, body aches
- Severe diarrhea or vomiting
- Numbness or tingling in your hands or feet
- Severe muscle pain, tenderness, or weakness
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia, bleeding problems, or muscle problems.
- This medicine may cause severe muscle problems.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Severe diarrhea or vomiting
- Unusual bleeding, bruising, or weakness
Colchicine Coupons & Prices
Colchicine
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Looking for a colchicine coupon? Colchicine is available as a low-cost generic, but the cash price can still vary widely from one pharmacy to the next, so comparing before you fill matters. Rx.com checks prices across more than 60,000 pharmacies so you can find the lowest cash price near you, no insurance required. Enter your ZIP above to see today's price on colchicine at pharmacies around you.
What is colchicine and how does it work?
Colchicine is an anti-gout agent in the alkaloid family. It works as an anti-inflammatory by inhibiting microtubules (tubulin), which quiets the inflammatory response that drives a gout attack. It is FDA-approved to prevent and treat acute gout flares in adults, to treat familial Mediterranean fever (FMF) in adults and children 4 years and older, and (as the brand Lodoco, 0.5 mg once daily) to reduce the risk of heart attack, stroke, coronary revascularization, and cardiovascular death in adults with established atherosclerotic cardiovascular disease or multiple cardiovascular risk factors.
It is important to know that colchicine is not a pain reliever. It does not treat pain that is unrelated to gout or FMF. It is also used off-label by some clinicians for conditions such as pericarditis and Behcet disease, but you should only take it for what your own provider has prescribed.
Colchicine cost without insurance and how to save
Colchicine is available as a generic, which typically makes it far more affordable than the brand-name versions (Colcrys, Mitigare, Lodoco, and Gloperba). Even so, cash prices for the same generic can differ a lot depending on which pharmacy you use, which is exactly why comparing pays off. You do not need insurance to use an Rx.com coupon price.
Enter your ZIP above to see today's colchicine price at pharmacies near you and pick the lowest one. If your provider prescribed brand-name Lodoco specifically, the manufacturer offers patient resources and any available savings program at its official page (lodoco.com/patient-resources); terms and eligibility vary, so check the manufacturer site for current details.
Colchicine alternatives and related gout medications
Colchicine is one of several medications used in gout care, and it is often used alongside others because they do different jobs. Colchicine helps with flares, while urate-lowering drugs work over the long term to reduce uric acid levels. Related options your provider may discuss include:
- allopurinol and febuxostat - daily medications that lower uric acid to help prevent future flares
- probenecid - helps the body clear more uric acid
- indomethacin - an anti-inflammatory sometimes used for acute gout pain
If you were prescribed a brand version of colchicine, you can compare prices on Colcrys, Mitigare, and Lodoco as well. Your provider will decide which combination is right for you.
Colchicine safety and side effects
The most common side effects of colchicine are gastrointestinal: diarrhea, nausea, vomiting, and abdominal pain. More serious risks include blood problems (such as low blood counts and, rarely, aplastic anemia) and muscle or nerve toxicity (including myopathy and rhabdomyolysis), which are more likely in people with kidney or liver impairment or those also taking statins or fibrates. People with significant kidney or liver impairment often need a dose adjustment.
Fatal overdoses have been reported in both adults and children, so always keep colchicine out of the reach of children. Life-threatening toxicity can occur when colchicine is combined with certain strong drug interactions (such as clarithromycin, ketoconazole, ritonavir, or cyclosporine); these combinations can be contraindicated or require dose reduction. This is general information, not medical advice - talk with your doctor or pharmacist about your other medications and the right dose for you before starting or changing colchicine.
This Colchicine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Colchicine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.