Probenecid Coupons & Prices

Looking for a probenecid coupon? Probenecid is an inexpensive generic medication used to treat chronic gout and to boost the levels of certain antibiotics, but the cash price still varies widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can find a low price near you. Enter your ZIP above to see today's price and print or show your free coupon at the counter.

What is probenecid and how does it work?

Probenecid is a uricosuric agent, meaning it helps the kidneys remove more uric acid from the body. In people with chronic gout and gouty arthritis, this lowers the level of uric acid in the blood, which over time reduces gout flares and the buildup that damages joints. It is a long-term, preventive treatment and is not used to relieve a sudden, acute gout attack. In fact, starting probenecid during an acute attack can make it worse, so treatment is usually begun only after the attack has settled.

Probenecid has a second, very different job. It slows how quickly the kidneys clear certain drugs, so it is also FDA-approved as an add-on to penicillin-type antibiotics (such as penicillin, ampicillin, methicillin, oxacillin, cloxacillin, and nafcillin) to raise and prolong their levels in the blood. The original brand names Benemid and Probalan have been discontinued, but probenecid remains widely available as a low-cost generic. A colchicine-probenecid combination is also available as a low-cost generic; the older branded versions (Col-Probenecid, Colbenemid) have been discontinued.

How much does probenecid cost without insurance?

Probenecid is an older generic, so it is generally an affordable medication even if you pay cash. That said, the price for the very same tablet can differ a lot depending on which pharmacy you use, so it pays to compare before you fill. A Rx.com coupon is free to use and works whether or not you have insurance; many people find the cash coupon price beats their copay.

To check the current price, enter your ZIP code above. Rx.com will show today's price at pharmacies near you across our network of more than 60,000 locations, and you can print the coupon or pull it up on your phone at the counter. There is no membership or signup required to use it.

Probenecid vs. other gout medications

Probenecid is one of several options for managing gout, and they work in different ways, so your provider chooses based on your kidney function, other health conditions, and how your body handles uric acid. Common alternatives and companion medicines include:

• Allopurinol and febuxostat lower uric acid by reducing how much the body makes, rather than by increasing how much the kidneys excrete. They are often first-choice long-term therapies.
• Colchicine is frequently prescribed alongside probenecid during the first months of treatment to help prevent the flares that can occur as uric acid levels shift.
• Colchicine-probenecid combines both medicines in one tablet.

Probenecid tends to work best in people with normal kidney function; it is not effective when kidney function is significantly reduced. Only your provider can decide which approach fits you, but Rx.com can help you compare the price on whichever one you are prescribed.

Safety and important warnings

Probenecid has no boxed warning, but there are important cautions. It should not be started during an acute gout attack and should not be used in children under 2 years of age, in people with certain blood disorders, or in those with uric acid kidney stones. Because it moves more uric acid through the kidneys, it can raise the risk of kidney stones, which is why drinking plenty of fluids (often 6 to 8 glasses of water a day) is recommended, and your provider may advise measures to keep the urine less acidic.

Probenecid interacts with many medicines. Aspirin and other salicylates can block its effect on uric acid, and probenecid can raise blood levels of drugs such as methotrexate (a potentially serious interaction), penicillins, and NSAIDs. Rare but serious reactions, including severe skin and allergic reactions, hemolytic anemia (especially in people with G6PD deficiency), and liver injury, have been reported. This is general information, not medical advice; tell your provider about every medication and supplement you take, and follow their guidance.